Adjusted regression analysis: Baseline B-cell subpopulations as predictors for IgG antibody titers.

IgG antibody concentration is calculated as the relative vaccine-specific IgG increase of the 7 Streptococcus pneumoniae polysaccharide serotypes contained in the PCV-7 vaccine from pre-vaccination baseline to 3, 4 and 9 months, measured by ELISA.B-cell counts are calculated as the routine lab lymphocyte count multiplied with the B-cell percentage of lymphocytes measured by flow cytometry.Adjusted for patient group (‘ART-naïve’, ‘impaired responders’, ‘ART-responders’), CPG7909 adjuvant (yes/no) and current smoker (yes/no).RC; Regression Coefficient (increase in log(µg IgG/ml) with 10-fold increase in cell counts/fractions), p; p-value, n; number of participants.Transitional; IgD+, IgM+, CD27−, CD38+ B cells, Naive; IgD+, IgM+/−, CD27−, CD38− B cells, MZ-like; marginal zone-like B cells (IgD+, IgM+, CD27+, CD38−), IgM-only memory; IgD−, IgM+, CD27+, CD38− B cells, ITS memory; isotype switched memory B cells (IgD−, IgM−, CD27+, CD38−), ITS plasmablasts; isotype switched plasmablasts (IgD−, IgM−, CD27+, CD38+).