Randomized Phase III Study of Maintenance Therapy With Bevacizumab, Pemetrexed, or a Combination of Bevacizumab and Pemetrexed Following Carboplatin, Paclitaxel and Bevacizumab for Advanced Non-Squamous NSCLC

RATIONALE: Drugs used in chemotherapy, such as paclitaxel and carboplatin, work in different
ways to stop the growth of tumor cells, either by killing the cells or by stopping them from
dividing. Monoclonal antibodies, such as bevacizumab, can block tumor growth in different
ways. Some block the ability of tumor cells to grow and spread. Others find tumor cells and
help kill them or carry tumor-killing substances to them. Bevacizumab may also stop the
growth of non-small cell lung cancer by blocking blood flow to the tumor. Pemetrexed disodium
may stop the growth of tumor cells by blocking some enzymes needed for cell growth. It is not
yet known whether giving bevacizumab or pemetrexed disodium alone or in combination is more
effective in treating non-squamous non-small cell lung cancer.

PURPOSE: This randomized phase III trial is studying bevacizumab and pemetrexed disodium
alone or in combination after induction therapy to see how well they work in treating
patients with advanced non-squamous non-small cell lung cancer.