Autologous fecal microbiota transfer in pediatric Crohn´s disease patients under treatment with exclusive enteral nutrition harbors major challenges - a feasibility test. EEN-microbiota for autologous FMT in pediatric CD

Based on the hypothesis that EEN-induced changes in microbial composition and function significantly contribute to treatment efficacy, we hypothesized that EEN-conditioned microbiota could be used in an autologous FMT approach to maintain remission in pediatric CD patients. We therefore aimed to evaluate the feasibility of at-home stool collection during EEN-induced remission and of further processing of fecal material into FMT capsules, including analysis of microbial composition and a complete safety screening for pathogens