Project - Immunologically active phenotype in PD-1/PD-L1 inhibitors with patients of advanced NSCLC

Immunotherapy in immunologically active tumors may improve prognosis of non-small cell lung carcinomas (NSCLC). Our objective was to develop a reliable and stable scoring system for the identification of immunologically active HNSCC and to evaluate its association with response to immunotherapies. A Hot Oral Tumor (HOT) score was developed using data from The Cancer Genome Atlas in human-papillomavirus negative head and neck squamous cell carcinomas; it was computed in 92 patients with early stage NSCLC treated with surgery to evaluate the prognostic impact of the HOT score.针对免疫激活型肿瘤的免疫治疗或可改善非小细胞肺癌（non-small cell lung carcinoma, NSCLC）患者的预后。本研究旨在构建一套可靠且稳定的评分系统，用于识别免疫激活型头颈部鳞状细胞癌（head and neck squamous cell carcinoma, HNSCC），并评估该评分系统与免疫治疗应答的相关性。热口腔肿瘤评分（Hot Oral Tumor, HOT）基于人类乳头瘤病毒（human-papillomavirus, HPV）阴性头颈部鳞状细胞癌的癌症基因组图谱（The Cancer Genome Atlas, TCGA）数据构建而成；本研究将该评分应用于92例接受手术治疗的早期非小细胞肺癌患者，以评估HOT评分的预后影响。