Definition and classification of individual interventions (coverage) (based on [22]).

aEndocrine therapy consists of 20 mg tamoxifen per day for 5 years.bDown-staging interventions cause a shift in stage distribution and are only modeled in combination with treatment of all stages (I–IV).cBAR was excluded as a standalone intervention in Costa Rica and Mexico.dPalliative care interventions are only applied to stage IV patients, and substitutes stage IV treatment.eThe (neo)adjuvant chemotherapy combination regimen consists of 7 cycles of Epirubicin, Fluorouracil and cyclophosphamide (FEC regimen) Given on an outpatient basis.fRadiotherapy includes a standard dose of 50 Gy given in 25 fractions of 2 Gy on an outpatient basis.gTrastuzumab is given for 8 months.