Knockdown and overexpression of C* proteins in Hela and HEK293 cells was investigated by RNA-Seq. Overall design: HeLa cells were transfected either with the indicated siRNAs and analyzed by RNA-Seq.

NIAID Data Ecosystem30

Whole genome bisulfite and TAB-Sequencing from sorted neurons in the adult mouse brain

神经元甲基化测序

MeCP2结合分析

Mutations in the gene encoding the methyl-CG binding protein MeCP2 cause neurological disorders including Rett syndrome. The di-nucleotide methyl-CG (mCG) is the canonical MeCP2 DNA recognition sequen

NIAID Data Ecosystem10

Cell type-specific alternative splicing during mammalian neuronal differentiation. Mus musculus

神经分化

植物可变剪接调控

Alternative precursor-mRNA splicing (AS) is a key regulation of gene expression and protein diversity. AS is highly happened in the nervous system and misregulation of AS caused neurological diseases.

NIAID Data Ecosystem30

Activation of the p53-MDM4 regulatory axis defines the anti-tumour response to PRMT5 inhibition through its role in regulating cellular splicing.. Activation of the p53-MDM4 regulatory axis defines the anti-tumour response to PRMT5 inhibition through its role in regulating cellular splicing.

PRMT5抑制剂抗肿瘤机制

植物可变剪接调控

Here we describe broad anti-proliferative activity of potent, selective, reversible inhibitors of protein arginine methyltransferase5 (PRMT5) including GSK3326595 in human cancer cell lines representi

NIAID Data Ecosystem10

Mus musculus strain:C57BL/6 Raw sequence reads. Mus musculus strain:C57BL/6

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