Dataset for the project "Novel tailored network-based rTMS treatments in Alzheimer's disease: an integrated multi-imaging approach" (GR-2016-02364718)

Specific Aim 1:

To test the efficacy of two network-based rTMS treatment protocols in reducing cognitive impairment. In the first protocol, the treatment will aim at stimulating the Default Mode Network (DMN) whereas the second protocol will target the Central Executive Network (CEN).

Specific Aim 2:

To investigate the neural mechanisms underlying response to treatment. We will investigate the modulations of brain reactivity, plasticity and connectivity induced by the treatments and how they correlate with the clinical response, thus defining quantitative markers of clinical improvement. To this aim, we will use an integrated multi-imaging approach, which will involve the use of innovative measures obtained with MRI and neurophysiological tools (TMS-EEG co-registration and theta burst stimulation - TBS protocols of rTMS).

The present dataset contains the following folders:

RawData_Aim1 [Unpublished Data]

-                Materials and Methods_RawData_Aim1

-                RawData_Aim1: a dataset (excel file) containing the following sheets:

o   Demographic data (sheet 1)

o   Cognitive data – primary outcome (sheet 2)

o   Cognitive data – secondary outcomes (sheet 3)

RawData_Aim2 [Unpublished Data]

-                Materials and Methods_RawData_Aim2

-                RawData_Aim2 - MRI: a dataset (excel file) containing the following sheet:

o   Sample (col A), scanner (col B) and timepoint (col C)

o   Rs-fMRI: functional connectivity (FC) values (col D-G)

o   DTI: microstructural integrity values: FA (col H-K) and MD (col L-O)

o   ASL: cerebral blood flow (CBF) values (col P-S)

       RawData_Aim2 - TMS-EEG: a folder containing individual folders for each patient, each of which includes the following subfolders:

o   T0: TEPs acquired for each target stimulation (l-CEN, r-CEN, l-DMN, r-DMN, Sham).

o   T1: TEPs acquired for each target stimulation (l-CEN, r-CEN, l-DMN, r-DMN, Sham).

o   T2: TEPs acquired for each target stimulation (l-CEN, r-CEN, l-DMN, r-DMN, Sham).

       RawData_Aim2 - TBS: a folder containing individual folders for each patient, each of which includes the following subfolders:

o   T0: MEPs acquired at baseline, at 0, 10 and 20 minutes after TBS.

o   T1: MEPs acquired at baseline, at 0, 10 and 20 minutes after TBS.

o   T2: MEPs acquired at baseline, at 0, 10 and 20 minutes after TBS.

 Restricted Access Conditions: Users must clarify how they intend to use data here uploaded and whether the research protocol has been approved by an Ethics committee. Data on unpublished results will be available, under the same restrictions, after publication.