Crystal structure of agonistic antibody 1618 fab domain bound to human 4-1BB.
收藏Protein Data Bank Japan2024-11-20 更新2026-03-28 收录
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Crystal structure of agonistic antibody 1618 fab domain bound to human 4-1BB. Descriptor: MANGANESE (II) ION, Tumor necrosis factor receptor superfamily member 9, heavy chain of Fab, ... Authors: Hakansson, M, Rose, N, Petersson, J, Enell Smith, K, Thorolfsson, M, von Schantz, L. Deposit date: 2022-02-16 Release date: 2023-01-25 Last modified: 2024-11-20 Method: X-RAY DIFFRACTION (2.31 Å) Cite: The Bispecific Tumor Antigen-Conditional 4-1BB x 5T4 Agonist, ALG.APV-527, Mediates Strong T-Cell Activation and Potent Antitumor Activity in Preclinical Studies. Mol.Cancer Ther., 22, 2023
结合人源4-1BB的激动型抗体1618 Fab结构域的晶体结构。描述项：二价锰离子（MANGANESE (II) ION）、肿瘤坏死因子受体超家族成员9（Tumor necrosis factor receptor superfamily member 9）、Fab重链（heavy chain of Fab）…… 作者：Hakansson, M、Rose, N、Petersson, J、Enell Smith, K、Thorolfsson, M、von Schantz, L。提交日期：2022-02-16，发布日期：2023-01-25，最后更新日期：2024-11-20。实验方法：X射线衍射（X-RAY DIFFRACTION，分辨率2.31 Å）。引用文献：《双特异性肿瘤抗原条件型4-1BB×5T4激动剂ALG.APV-527在临床前研究中可介导强效T细胞活化与显著抗肿瘤活性》，Mol.Cancer Ther., 22, 2023
创建时间：
2022-02-16
