Continuous glucose monitoring profiles in healthy non-diabetic participants: a multicenter prospective study

Context: Use of continuous glucose monitoring (CGM) is increasing for insulin-requiring patients with diabetes. While data on glycemic profiles of healthy, non-diabetic individuals exists for older sensors, assessment of glycemic metrics with new generation CGM devices is lacking. Objective: To establish reference sensor glucose ranges in healthy, non-diabetic individuals across different age groups, using a current generation CGM sensor. Design: Multicenter, prospective study. Setting: 12 centers within the T1D Exchange Clinic Network. Patients or Participants: Non-pregnant, healthy, non-diabetic children and adults (age ≥6 years); with non-obese body mass index. Intervention: A blinded Dexcom G6 CGM, with once daily calibration, was worn for up to 10 days in each participant. Main Outcome Measure: CGM metrics of mean glucose, hyperglycemia, hypoglycemia, and glycemic variability. Results: 153 participants (age 7-80 years) were included in the analyses. Mean average glucose was 98-99 ...