Continuous glucose monitoring profiles in healthy non-diabetic participants: a multicenter prospective study

Context: Use of continuous glucose monitoring (CGM) is increasing for insulin-requiring patients with diabetes. While data on glycemic profiles of healthy, non-diabetic individuals exists for older sensors, assessment of glycemic metrics with new generation CGM devices is lacking. Objective: To establish reference sensor glucose ranges in healthy, non-diabetic individuals across different age groups, using a current generation CGM sensor. Design: Multicenter, prospective study. Setting: 12 centers within the T1D Exchange Clinic Network. Patients or Participants: Non-pregnant, healthy, non-diabetic children and adults (age ≥6 years); with non-obese body mass index. Intervention: A blinded Dexcom G6 CGM, with once daily calibration, was worn for up to 10 days in each participant. Main Outcome Measure: CGM metrics of mean glucose, hyperglycemia, hypoglycemia, and glycemic variability. Results: 153 participants (age 7-80 years) were included in the analyses. Mean average glucose was 98-99 ...研究背景：针对需要胰岛素治疗的糖尿病患者，连续血糖监测（continuous glucose monitoring, CGM）的应用正日益普及。尽管针对前代传感器的健康非糖尿病个体血糖谱已有相关数据积累，但针对新一代连续血糖监测设备的血糖指标评估仍存在不足。 研究目的：采用当前一代连续血糖监测传感器，建立不同年龄组健康非糖尿病个体的参考传感器血糖范围。 研究设计：多中心前瞻性研究。 研究地点：T1D Exchange Clinic Network旗下的12家研究中心。 研究对象：无妊娠情况、健康非糖尿病的儿童及成人（年龄≥6岁），且体重指数（body mass index, BMI）处于非肥胖范围。 干预措施：所有受试者佩戴盲法德康（Dexcom）G6连续血糖监测传感器，每日进行一次校准，佩戴时长最长可达10天。 主要结局指标：涵盖平均血糖、高血糖、低血糖及血糖变异性的连续血糖监测指标。 研究结果：共计153名受试者（年龄7~80岁）纳入本次分析，平均血糖均值为98~99……