Steady-state total mass of complex sphingolipid sub-populations in SL-E model under different experimental conditions, after 60 minutes.

Wild type condition is represented by the sum of the basal values; the other experimental conditions correspond to fold changes with respect to the wild type after decreasing the specific activity of serine palmitoyl transferase (X157), IPC synthase (X133), and ceramide synthase (X134) to 1% or 12.5%. Complex sphingolipids: IPC in Golgi compartment plus plasma membrane (X8+X20), MIPC in Golgi compartment plus plasma membrane (X18+X21), M(IP)2C in Golgi compartment plus plasma membrane (X19+X22). CS represents the total of complex sphingolipids.