Glycosamino Acids: New Building Blocks for Combinatorial Synthesis

In order to produce inexpensive, chemically diverse carbohydrate
building blocks more amenable for use
in combinatorial organic synthesis, amine and carboxylic acid
functional groups were incorporated into several
monosaccharides. A series of 12 new glycosamino acids was prepared
from commercially available starting materials.
Conventional peptide synthesis solution coupling techniques were
used to ligate glycosamino acids, producing
oligomeric “glycotides”. Finally, a library of glycotides was
produced by coupling of a glycosamino acid mixture
to a rigid template.