Strain-specific differences in brain gene expression in a hydrocephalic mouse model with motile cilia dysfunction. Strain-specific differences in brain gene expression in a hydrocephalic mouse model with motile cilia dysfunction

Analysis of strain-specific differences in gene expression in brains from a hydrocephalic mouse model of primary ciliary dyskinesia. The results identify genes that are differentially expressed between C57BL6/J and 129S6/SvEvTac brains. These genes encode proteins that function in a variety of cellular processes and include some that are relevant to hydrocephalus and cilia function, providing insight into the mechanisms underlying susceptibility to hydrocephalus. Overall design: Total RNA was isolated from whole brains from wild type and nm1054 mutant mice on the C57BL6/J and 129S6/SvEvTac backgrounds at postnatal day 1 for microarray analysis.