CryoEM structure of human PS2-containing gamma-secretase
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CryoEM structure of human PS2-containing gamma-secretase Descriptor: 1,2-DIACYL-SN-GLYCERO-3-PHOSPHOCHOLINE, 2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... Authors: Guo, X, Wang, Y, Zhou, J, Jin, C, Wang, J, Jia, B, Jing, D, Yan, C, Lei, J, Zhou, R, Shi, Y. Deposit date: 2022-06-18 Release date: 2022-11-02 Last modified: 2025-07-02 Method: ELECTRON MICROSCOPY (3.4 Å) Cite: Molecular basis for isoform-selective inhibition of presenilin-1 by MRK-560. Nat Commun, 13, 2022
含人源PS2的γ-分泌酶冷冻电镜（CryoEM）结构 描述项：1,2-二酰基-sn-甘油-3-磷酸胆碱、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖、2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖-(1→4)-2-乙酰氨基-2-脱氧-β-D-吡喃葡萄糖…… 作者：Guo, X、Wang, Y、Zhou, J、Jin, C、Wang, J、Jia, B、Jing, D、Yan, C、Lei, J、Zhou, R、Shi, Y 提交日期：2022-06-18 发布日期：2022-11-02 最后修改日期：2025-07-02 方法：电子显微镜（分辨率3.4 Å） 引用：MRK-560介导的早老素1亚型选择性抑制的分子机制. 《自然·通讯》，13，2022
