Anatomical Structures, Cell Types, plus Biomarkers (ASCT+B) table for Kidney v1.2

Anatomical Structures, Cell Types, plus Biomarkers (ASCT+B) tables aim to capture the nested part_of structure of anatomical human body parts, the typology of cells, and biomarkers used to identify cell types. The tables are authored and reviewed by an international team of experts. The kidney ASCT+B tables are generated from a variety of publicly available human kidney datasets and from data generated by HuBMAP and KPMP consortia. Most of the markers listed are observed in more than one study or orthogonally validated. Note that these are predicted markers and a single marker to annotate a cell type is not likely sufficient or specific. Therefore, these are just a guide, more accurate annotation should be done using the entire set of enriched genes in a cluster. The cell types shown here are at much higher granularity, although general markers for many of the structures are also shown. There is a tradeoff in uncertainty of cell type annotation with higher granularity and as spatial validation approaches become more robust we will be accordingly revising these.解剖结构、细胞类型及生物标志物（Anatomical Structures, Cell Types, plus Biomarkers, 简称ASCT+B）表格旨在完整呈现人体解剖部位的嵌套从属结构、细胞分类体系，以及用于鉴定细胞类型的生物标志物。该表格由国际专家团队编写并审核。肾脏ASCT+B表格的构建基于多种公开可用的人类肾脏数据集，以及HuBMAP与KPMP联盟产生的相关研究数据。所列多数标志物已在多项独立研究中被观测到，或经过正交验证。请注意，此类标志物均为预测所得，仅依靠单一标志物对细胞类型进行注释，通常难以满足特异性与充分性要求。因此，本表格仅作参考，更为精准的细胞类型注释应基于聚类簇内全部富集基因的集合完成。尽管本表格同时收录了多数解剖结构的通用标志物，但此处所列的细胞类型具有更高的分型粒度。细胞类型注释的不确定性与分型粒度存在权衡关系；随着空间验证方法愈发可靠，我们将对本表格进行相应修订。