Total CD4+T cell counts in PB (cells/ µL) 10 years after commencement of therapy when therapy is delivered to CD4+T cells, and ×4 virus can develop.

Mean total CD4+T cell counts in PB (cells/ µL) 10 years after commencement of therapy when therapy is delivered to CD4+T cells, with ×4 virus included in the simulations. Monte Carlo sampling with 100 trials (repeated sampling of parameter from a uniform distribution, see Methods) was performed for each case shown. The same scenarios as in Table 1 were simulated.