RNA sequencing in POLG-iPSC derived brain cells. RNA sequencing in POLG-iPSC derived brain cells

The pupose of this study is to explore tanalysis to investigate the different phenotypes between homozygous and compound heterozygous genotypes in different brain cell types, including patient-specific fibroblasts, iPSCs and iPSCs-derived neural stem cells (NSCs), and astrocytes. Overall design: Examination of mRNA profile in iPSC, ESC and their-derived NSCs and astrocytes. ***Raw data for human samples not available due to patient privacy concerns***