IMT with ALK fusion

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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA1019077

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Patients with inflammatory myofibroblastic tumor of the colon with TPM3-ALK fusion.

创建时间：

2023-09-19

IMT with ALK fusion

Patients with inflammatory myofibroblastic tumor of the colon with TPM3-ALK fusion.

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ALK fusion partners.

*Histopathological evidence is lacking. Abbreviations: ALCL, anaplastic large cell lymphoma; LBCL, large B-cell lymphoma; IMT, inflammatory myofibroblastic tumor; NSCLC, non-small cell lung carcinoma;

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ALK fusion proteins bind IRS

IRS1 binds the NPM-ALK fusion protein through tyrosine residue 167. Mutation of this residue abrogates IRS1 binding, but the NPM-ALK Y167 mutant is still able to support the transforming activity of t

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ALK fusion partners.

Figshare2015-12-02 更新00

Transcription analysis of CBX3::ALK Fusion and EML4-ALK Fusion that drives ALK Activation

Kinase gene fusions are critical oncogenic drivers and key targets in precision oncology. Here, we report a previously undescribed out-of-frame CBX3::ALK fusion identified in metastatic melanoma. Rema

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