Human ALS sciatic nerve investigation with nanoXPCT

We propose to investigate human ALS sciatic nerve fiber and obtain a direct quantification of axonal damage and its spatial distribution. We intend to measure 12 samples of human sciatic nerve at different time-points of the disease by means of nano-XPCT. Our results will be correlated with results obtained using complementary techniques and with the clinical data of the corresponding patients. We believe that our experiment may potentially provide a contribution to the debate about the site of disease origin.