Location of the nucleotide (non coding regions) or amino acid (coding regions) differences in both genome segments between 88180, Cu-1 and typical vvIBDV strain D6948 (Acc No AF240686 and AF240687 for segments A and B, respectively).

The 88180 sequence was used as a reference and only nucleotides or amino acids differences were presented. Italicised letters indicate positions that have been reported to be typical of vvIBDV, in VP2 and VP1. For the segment A, in the left column, −1, to −4 numbers correspond to the presence of four additional amino acids in the VP5 protein of the typical vvIBDV strain D6948 (153 aa long) compare to 88180 or Cu1 strains (149 aa long). In the second large ORF partly overlapping VP5, pVP2 corresponds to aa 1 to 512, VP4 to aa 513 to 755 and VP3 to aa 756 to 1012. For the segment B (878 aa), domain 1 contains the N-terminal domain (N-ter) and Finger 1 (F1) subdomains, the catalytic domain contain the Palm 1 (P1), Finger 2 (F2) and Palm 2 (P2) sub-domains and domain 2 contains the Palm 2 (P2), Thumb sub-domains (T) and the C-terminal region (C-ter) as determined from the tridimensional structure of the IBDV polymerase recently solved [21], [22].