Gene Expression Profiling of SPOP Knocked Down Cell. Homo sapiens
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https://www.ncbi.nlm.nih.gov/bioproject/PRJNA392902
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资源简介：
SPOP is one of the most frequent mutated genes in prostate cancer. In the current study, we identified CCNE1 as its substrate. SPOP directly interacts with CCNE1, poly-ubiquitinates CCNE1 in vivo and in vitro, and represses cancer-related phenotypes induced by CCNE1 expression. Thus, we reveal a new mechanism for SPOP in repressing prostate cancer tumorigenesis. Overall design: SPOP was knocked down by siRNA in DU145 and 769-P, the gene expression profile was studied by RNA sequencing
创建时间：
2017-07-03
