Pd-Catalyzed Site-Selective <i>p</i>‑Hydroxyphenyloxylation of Benzylic α‑C(sp<sup>3</sup>)–H Bonds with 1,4-Benzoquinone
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资源简介：
A Pd-catalyzed, site-selective p-hydroxyphenyloxylation of benzylic α-C(sp3)–H bonds with 1,4-benzoquinone using thioamide as a directing group is reported. 1,4-Benzoquinone is employed as the p-hydroxyphenyloxy source without extra oxidants. This method exclusively gives site selectivity at α-C(sp3)–H bonds rather than the usual β-C(sp3)–H bonds through C–H activation mode. The reactions proceed with high functional group tolerance in yields of 42–93%.
创建时间：
2016-11-14
