Local activation of CA1 pyramidal cells induces theta phase precession

Hippocampal theta phase precession is involved in spatiotemporal coding and generating multineural spike sequences, but how precession originates remains unresolved. To determine whether precession can be generated directly in hippocampal area CA1 and disambiguate multiple competing mechanisms, we used closed-loop optogenetics to impose artificial place fields in pyramidal cells of mice running on a linear track. More than a third of the CA1 artificial fields exhibited synthetic precession that persisted for a full theta cycle. In contrast, artificial fields in the parietal cortex did not exhibit synthetic precession. The findings are incompatible with precession models based on inheritance, dual-input, spreading activation, inhibition-excitation summation, or somato-dendritic competition. Thus, a precession generator resides locally within CA1., , , # Local activation of CA1 pyramidal cells induces theta phase precession

This dataset encompasses extracellular recordings obtained from freely-moving mice, integral to the research presented in our manuscript entitled “Local activation of CA1 pyramidal cells induces theta phase precession”. The data are available at two levels of processing.

**1.    Processed data**: MATLAB variable files containing details regarding each putative pyramidal cell (PYR) and interneuron (INT) described in the manuscript. These consist of:

* **CA1_units.mat**: including 1,095 PYRs and 329 INTs recorded from hippocampal region CA1.
* **PPC_units.mat**: including 195 PYRs recorded from the posterior parietal cortex (PPC).

**2. Raw data:** Neuronal and auxiliary data recorded during every experimental session. The data include 69 sessions from CA1 and 22 sessions from the PPC. Files from every session are compressed into a .zip file carrying the session name. A list of each session, the animal it wa...