Local activation of CA1 pyramidal cells induces theta phase precession

Hippocampal theta phase precession is involved in spatiotemporal coding and generating multineural spike sequences, but how precession originates remains unresolved. To determine whether precession can be generated directly in hippocampal area CA1 and disambiguate multiple competing mechanisms, we used closed-loop optogenetics to impose artificial place fields in pyramidal cells of mice running on a linear track. More than a third of the CA1 artificial fields exhibited synthetic precession that persisted for a full theta cycle. In contrast, artificial fields in the parietal cortex did not exhibit synthetic precession. The findings are incompatible with precession models based on inheritance, dual-input, spreading activation, inhibition-excitation summation, or somato-dendritic competition. Thus, a precession generator resides locally within CA1., , , # Local activation of CA1 pyramidal cells induces theta phase precession This dataset encompasses extracellular recordings obtained from freely-moving mice, integral to the research presented in our manuscript entitled “Local activation of CA1 pyramidal cells induces theta phase precession”. The data are available at two levels of processing. **1.   Processed data**: MATLAB variable files containing details regarding each putative pyramidal cell (PYR) and interneuron (INT) described in the manuscript. These consist of: * **CA1_units.mat**: including 1,095 PYRs and 329 INTs recorded from hippocampal region CA1. * **PPC_units.mat**: including 195 PYRs recorded from the posterior parietal cortex (PPC). **2. Raw data:** Neuronal and auxiliary data recorded during every experimental session. The data include 69 sessions from CA1 and 22 sessions from the PPC. Files from every session are compressed into a .zip file carrying the session name. A list of each session, the animal it wa...海马体θ相位预偏转（theta phase precession）参与时空编码与多神经元尖峰序列的生成，但其起源机制至今尚未阐明。为验证相位预偏转是否可直接在海马CA1区产生，并厘清多种竞争性机制，我们采用闭环光遗传学（closed-loop optogenetics）手段，在小鼠于线性跑道奔跑时，对其锥体神经元施加人工位置野（place field）。超过三分之一的CA1人工位置野呈现出完整θ周期持续的合成性相位预偏转。与之相对，顶叶皮层的人工位置野并未表现出合成性相位预偏转。本研究结果与基于遗传继承、双输入、扩散激活、抑制-兴奋总和或躯体-树突竞争的相位预偏转模型均不兼容。由此可见，相位预偏转的产生器定位于CA1局部区域。 # CA1锥体神经元局部激活诱导θ相位预偏转 本数据集包含自由活动小鼠的细胞外记录（extracellular recordings），对应于我们发表在题为《CA1锥体神经元局部激活诱导θ相位预偏转》的研究论文中的实验数据。该数据集提供两种处理层级的数据： **1. 处理后数据**：MATLAB变量文件（MATLAB variable files），包含论文中描述的每一个疑似锥体神经元（PYR）和中间神经元（INT）的详细信息，具体包括： * **CA1_units.mat**：收录了从海马CA1区记录到的1095个锥体神经元与329个中间神经元。 * **PPC_units.mat**：收录了从后顶叶皮层（posterior parietal cortex, PPC）记录到的195个锥体神经元。 **2. 原始数据**：每次实验会话期间记录的神经元与辅助生理数据。本数据集包含69次CA1区实验会话与22次后顶叶皮层实验会话。每一次会话的文件均被压缩为以会话名称命名的.zip压缩包。各会话的完整列表、对应实验动物……