Efficacy of bacterial cellulose membrane for the treatment of lower limbs chronic varicose ulcers: a randomized and controlled trial

ABSTRACT Objective: to evaluate the efficacy of Bacterial Cellulose (BC) membrane dressings in the treatment of lower limb venous ulcers. Methods: we carried out a prospective, randomized, controlled study of 25 patients with chronic venous ulcer disease in the lower limbs from the Angiology and Vascular Surgery Service of the Federal University of Pernambuco Hospital and from the Salgado Polyclinic of the County Health Department, Caruaru, Pernambuco. We randomly assigned patients to two groups: control group, receiving dressings with triglyceride oil (11 patients) and experimental group, treated with BC membrane (14 patients). We followed the patients for a period of 120 days. Results: There was a reduction in the wound area in both groups. There were no infections or reactions to the product in any of the groups. Patients in the BC group showed decreased pain and earlier discontinuation of analgesic use. Conclusion: BC membrane can be used as a dressing for the treatment of varicose ulcers of the lower limbs.摘要 研究目的：评估细菌纤维素（Bacterial Cellulose，BC）膜敷料治疗下肢静脉溃疡的临床疗效。 研究方法：本研究针对巴西伯南布哥州卡鲁阿鲁县卫生局萨尔加多综合诊所及伯南布哥联邦大学医院血管病与血管外科科室收治的25例下肢慢性静脉溃疡患者，开展一项前瞻性随机对照研究。将患者随机分为两组：对照组（11例）采用甘油三酯油敷料治疗，实验组（14例）采用BC膜敷料治疗，对所有患者进行为期120天的随访。 研究结果：两组患者的创面面积均较基线有所缩小；两组均未出现创面感染或敷料相关不良反应；BC膜敷料组患者疼痛症状显著缓解，且更早停用镇痛药物。 研究结论：细菌纤维素膜可作为下肢静脉曲张性溃疡的治疗敷料。