Crystal structure of human protein kinase CK2 in complex with the inhibitor CX-5011

Protein Data Bank Japan2023-09-06 更新2026-03-21 收录

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Crystal structure of human protein kinase CK2 in complex with the inhibitor CX-5011 Descriptor: 5-[(3-ethynylphenyl)amino]pyrimido[4,5-c]quinoline-8-carboxylic acid, Casein kinase II subunit alpha, SULFATE ION Authors: Battistutta, R, Papinutto, E, Lolli, G, Pierre, F, Haddach, M, Ryckman, D.M. Deposit date: 2010-10-25 Release date: 2011-09-07 Last modified: 2023-09-06 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Unprecedented selectivity and structural determinants of a new class of protein kinase CK2 inhibitors in clinical trials for the treatment of cancer. Biochemistry, 50, 2011

人源蛋白激酶CK2（Protein Kinase CK2）与抑制剂CX-5011结合的晶体结构描述符：5-[(3-乙炔基苯基)氨基]嘧啶并[4,5-c]喹啉-8-羧酸、酪蛋白激酶II α亚基、硫酸根离子作者：Battistutta, R、Papinutto, E、Lolli, G、Pierre, F、Haddach, M、Ryckman, D.M. 沉积日期：2010-10-25 发布日期：2011-09-07 最后修改日期：2023-09-06 实验方法：X射线衍射（分辨率1.9 Å）引用文献：用于癌症治疗的临床试验中新一类蛋白激酶CK2抑制剂的空前选择性及结构决定因素，《生物化学》，50卷，2011年

创建时间：

2010-10-25