An Approach to the Core Structure of Leiodermatolide
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https://figshare.com/articles/dataset/An_Approach_to_the_Core_Structure_of_Leiodermatolide/2655991
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The synthesis of the 16-membered core structure of leiodermatolide 40 has been achieved in 26 linear steps starting from (R)-Roche ester. The key steps in the synthesis of 40 are a Stille cross-coupling between two main fragments 11 and 33 having roughly equal size. For the trisubstituted C4/C5 double bond a carbometalation reaction followed by a Suzuki coupling was used. A Yamaguchi macrolactonization furnished macrolactone 39.
创建时间：
2011-05-06
