B-ALL TYK2 sequencing

B cell precursor acute lymphoblastic leukaemia (B-ALL) is a malignancy of lymphoid progenitor cells with altered genes including the non-receptor Janus kinase (JAK) gene family. Tyrosine kinase 2 (TYK2) is a high polymorphic member of the JAK family involved in signal transduction of cytokines. The main goal of this study was to search for disease-associated TYK2 variants in bone marrow samples from B-ALL patients at diagnosis by next-generation sequencing.