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A Global Thermodynamic-Kinetic Model Capturing the Hallmarks of Liquid-Liquid Phase Separation and Amyloid Aggregation

Name: A Global Thermodynamic-Kinetic Model Capturing the Hallmarks of Liquid-Liquid Phase Separation and Amyloid Aggregation
Creator: Clemson University; Monash University, Australia
Published: 2025-05-23T00:00:00+08:00

Zenodo2025-05-23 更新2026-04-07 收录

液-液相分离

淀粉样蛋白聚集

数据链接：

https://zenodo.org/doi/10.5281/zenodo.15499212 数据链接链接失效反馈

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资源简介：

Detailed explanations are provided in README_file.docs.

应用场景：

提供机构：

Clemson University; Monash University, Australia

创建时间：

2025-05-23

结直肠癌分子机制

液-液相分离

Liquid-liquid phase separation (LLPS) is a burgeoning concept in cell biology, which was associated with miRISC machinery. However, most studies about LLPS are based on overexpression of core proteins

NIAID Data Ecosystem210

Additional file 4 of Amyloid fibril proteomics of AD brains reveals modifiers of aggregation and toxicity

阿尔茨海默病蛋白质组学

淀粉样蛋白聚集

Additional file 4: Table S2. List of proteins identified in label-free MS analysis of amyloid fibrils isolated from mouse cortices. Proteins identified with a higher abundance in purified fibrils (N =

Figshare2023-11-21 更新80

Face to face contact distances of CC interface double layers of human amylin, rat amylin and their cross-seeded oligomers (human amylin|rat amylin).

淀粉样蛋白聚集

粒子间距离分析

Hydrophobic contact of Cα−Cα distances (Å) between the residues L27/G33, S29/N31, N31/S29 and G33/L27 of human amylin and L27/G33, P29/N31, N31/P29 and G33/L27 of rat amylin and their hetero-assembly.

NIAID Data Ecosystem50

Single layer and double layer decamer models and simulations conditions.

蛋白质结构建模与模拟

淀粉样蛋白聚集

SL marks single layer decamers and DL double layer decamers. The symbol * marks the mixed rat-human amylin complexes, where the first five strands are from the human amylin sequences and the last five

NIAID Data Ecosystem80

RNA-seq and ribosome profiling of heat shocked wild type and Mettl14 -/- mouse embryonic stem cells. RNA-seq and ribosome profiling of heat shocked wild type and Mettl14 -/- mouse embryonic stem cells

m6A修饰

液-液相分离

N6-methyladenosine (m6A) is a dynamic and reversible nucleotide modification in mRNA. m6A alters mRNA fate, but it is unclear why the effects of m6A can vary in different cellular contexts. Here we sh

NIAID Data Ecosystem50

A Global Thermodynamic-Kinetic Model Capturing the Hallmarks of Liquid-Liquid Phase Separation and Amyloid Aggregation

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