Anti-HBc IgM associates with acute flare and HBeAg/HBsAg loss in chronic hepatitis B patients with acute exacerbation

A total of 419 chronic hepatitis B (CHB) patients with acute exacerbation (AE) in Chongqing, China were included in this study to investigate the values of hepatitis B core antibody (anti-HBc) IgM in CHB-AE. The prevalence, clinical characteristics of anti-HBc IgM, and its relationship with the outcomes of CHB were assessed.