General and Scalable Approach to Trifluoromethyl-Substituted Cyclopropanes

CF3-cyclopropanes with aliphatic, aromatic,
and even
heteroaromatic substituents were prepared on a multigram scale by
deoxyfluorination of cyclopropane carboxylic acids or their salts
with sulfur tetrafluoride. For labile α-pyridine acetic acids,
only the use of their potassium salts allowed to obtain the needed
products. Derivatization of CF3-cyclopropanes into building
blocks ready for direct use in medicinal chemistry was performed.