Engineered conjugation of lysine-specific molecular tweezers with ExoS derived peptidic inhibitor enhance affinity towards target protein 14-3-3 through ditopic binding
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Engineered conjugation of lysine-specific molecular tweezers with ExoS derived peptidic inhibitor enhance affinity towards target protein 14-3-3 through ditopic binding Descriptor: 14-3-3 protein sigma, 2-[4-[2-[hydroxy-[[(1R,5S,9S,16R,20R,24S,28S,35R)-22-phosphonooxy-3-tridecacyclo[22.14.1.15,20.19,16.128,35.02,23.04,21.06,19.08,17.010,15.025,38.027,36.029,34]dotetraconta-2,4(21),6(19),7,10,12,14,17,22,25(38),26,29,31,33,36-pentadecaenyl]oxy]phosphoryl]oxyethyl]triazol-1-yl]acetic acid, Exoenzyme S, ... Authors: Guillory, X, Ottmann, C. Deposit date: 2020-03-02 Release date: 2021-03-31 Last modified: 2026-01-21 Method: X-RAY DIFFRACTION (2.5 Å) Cite: Supramolecular Enhancement of a Natural 14-3-3 Protein Ligand. J.Am.Chem.Soc., 143, 2021
将赖氨酸特异性分子镊子与ExoS（外分泌酶S）衍生肽抑制剂进行工程化缀合，通过双位点结合提升对靶蛋白14-3-3的亲和力
数据集描述项：14-3-3 σ蛋白（14-3-3 protein sigma）、2-[4-[2-[羟基-[[(1R,5S,9S,16R,20R,24S,28S,35R)-22-膦酰氧基-3-十三环[22.14.1.15,20.19,16.128,35.02,23.04,21.06,19.08,17.10,15.025,38.027,36.029,34]四十四碳-2,4(21),6(19),7,10,12,14,17,22,25(38),26,29,31,33,36-十五烯基]氧基]膦酰基]氧基乙基]三唑-1-基]乙酸、外分泌酶S……
作者：Guillory X、Ottmann C
提交日期：2020-03-02
发布日期：2021-03-31
最后修改日期：2026-01-21
实验方法：X射线衍射（X-RAY DIFFRACTION，2.5埃）
引用文献：《天然14-3-3蛋白配体的超分子增强》，《美国化学会志（J.Am.Chem.Soc.）》，第143卷，2021年
创建时间：
2020-03-02
