NextGen Consortium: GENESiPS Study: Identifying the Gene Networks of Insulin Resistance

RNA-seq transcriptome profiling of human induced pluripotent stem cells to characterize gene expression variation across individuals and within multiple iPSC lines from the same individual The purpose of this study was to analyze the potential differential responses to HMGCR inhibition of insulin sensitive versus insulin resistant human iPSC lines. Donor erythroblast or activated T-cells were reprogrammed with a Sendai viral vector coding for reprogramming factors. IPSC lines were propagated for ~9 passages before RNA sequencing **Please note that addtional sample records (GSM5100626- GSM5100649) have been included on Feb 22, 2021; Human iPSC lines are incubated in the presenceof Atorvastatin and gene expression changes are measured through RNAseq.