Crystal Structure of human FABP4 in complex with 5-[(4-chloro-3-phenoxyphenyl)methyl]-1H-tetrazole, i.e. SMILES N1N=NN=C1Cc1cc(c(cc1)Cl)Oc1ccccc1 with IC50=0.291 microM

Crystal Structure of human FABP4 in complex with 5-[(4-chloro-3-phenoxyphenyl)methyl]-1H-tetrazole, i.e. SMILES N1N=NN=C1Cc1cc(c(cc1)Cl)Oc1ccccc1 with IC50=0.291 microM Descriptor: 5-[(4-methyl-3-phenoxyphenyl)methyl]-1H-tetrazole, Fatty acid-binding protein, adipocyte, ... Authors: Ehler, A, Benz, J, Obst, U, Sweeney, Z, Rudolph, M.G. Deposit date: 2023-04-27 Release date: 2023-06-14 Last modified: 2025-08-13 Method: X-RAY DIFFRACTION (1.12 Å) Cite: A high-resolution data set of fatty acid-binding protein structures. III. Unexpectedly high occurrence of wrong ligands. Acta Crystallogr D Struct Biol, 81, 2025

人源脂肪酸结合蛋白4（Fatty acid-binding protein 4, FABP4）与5-[(4-氯-3-苯氧基苯基)甲基]-1H-四氮唑（其SMILES表达式为N1N=NN=C1Cc1cc(c(cc1)Cl)Oc1ccccc1，半最大效应浓度IC50=0.291 μM）共晶的晶体结构。描述符：5-[(4-甲基-3-苯氧基苯基)甲基]-1H-四氮唑、脂肪酸结合蛋白、脂肪细胞型……。作者：Ehler A、Benz J、Obst U、Sweeney Z、Rudolph M.G.。保藏日期：2023-04-27；发布日期：2023-06-14；最后修改日期：2025-08-13。实验方法：X射线衍射（分辨率1.12 埃）。引用文献：《脂肪酸结合蛋白结构高精度数据集。Ⅲ. 错误配体的意外高发生率》，发表于《Acta Crystallogr D Struct Biol》2025年第81卷。