PIWI-associated RNAs (piRNAs) support germline by suppressing retrotransposons and genes. In mice, piRNAs are essential for spermatogenesis but not oogenesis. To test how this applies to other mammals
Although immunotherapy has revolutionized cancer treatment, only a subset of patients demonstrates durable clinical benefit. Definitive predictive biomarkers and targets to overcome resistance remain
PIWI-clade Argonaute proteins silence transposon expression in animal gonads. Their target specificity is defined by bound ~23-30nt piRNAs that are processed from single-stranded precursor transcripts
Sequencing analyses of total mRNAs in delta-mbt-OSC and OSC (Control). Sequencing analyses of total small RNA, and Piwi-bound, Aub-bound, AGO3-bound piRNAs in delta-mbt-OSCs.
