Clostridium sp. HCS.1 Genome sequencing. Clostridium sp. HCS.1

Steroid modifications in the gut microbiome have high potential for clinical relevance, yet much remains unknown about their underlying molecular mechanisms. Here, we describe a novel Clostridium strain, which possesses a previously uncharacterized promiscuous ketosteroid delta-4 reductase, as well as a novel delta-1 reductase capable of acting on synthetic corticosteroids.