Effect of EPO on Plasma Cytokines in HS-65BV+VP.

Samples were available for each of the 12 control (CTR) pigs including the 10 that survived at 72 hours; but, for only 10 of the erythropoietin (EPO) treated pigs, which included all the survivors. Values are mean ± SD showing also the median with interquartile range in brackets as values for several time events were not normally distributed. BR, blood reinfusion; IL, interleukin; TNF-α, tumor necrosis factor-α. The data was analyzed using two-way repeated measures ANOVA. There was no overall statistically significant treatment effect. There was a statistically significant time effect for IL-8 (p = 0.011), IL-10 (p≤0.001) and TNF-α (p = 0.006) and there was a borderline statistically significant interactions between treatment and time for IL-10 (p = 0.062). †p≤0.003 denotes a statistically significant difference between groups at the specified time point. ap≤0.05, bp≤0.001 denote statistically significant differences from baseline within each group using the Holm-Sidak test for multiple comparisons.Effect of EPO on Plasma Cytokines in HS-65BV+VP.