Programming the Curvatures in Reconfigurable DNA Domino Origami by Using Asymmetric Units

The
DNA origami technique is a robust method for the design of
DNA nanostructures with prescribed shapes, including complex curved
geometries. In addition to static structures, dynamic DNA origami
has been used to construct sophisticated nanomachines that can reconfigure
their shapes in response to external stimuli. Here, we report a new
method to design DNA origami structures that can transform between
a noncurved conformation and curved conformation. The reconfigurable
structures are developed on the basis of dynamic DNA domino origami,
which can transform in a cascading process initiated by trigger DNA
strands. The degree of curvature could be programmed by tuning the
sizes of DNA units within the origami.