Liu2012 - Genome-scale metabolic network of Scheffersomyces stipitis (iTL885)

Liu2012 - Genome-scale metabolic network of Scheffersomyces stipitis (iTL885)

This model is described in the article:

A constraint-based model of
Scheffersomyces stipitis for improved ethanol production.

Liu T, Zou W, Liu L, Chen J.
Biotechnol Biofuels 2012; 5(1):
72
Abstract:

UNLABELLED: BACKGROUND: As one of the best xylose
utilization microorganisms, Scheffersomyces stipitis exhibits
great potential for the efficient lignocellulosic biomass
fermentation. Therefore, a comprehensive understanding of its
unique physiological and metabolic characteristics is required
to further improve its performance on cellulosic ethanol
production. RESULTS: A constraint-based genome-scale metabolic
model for S. stipitis CBS 6054 was developed on the basis of
its genomic, transcriptomic and literature information. The
model iTL885 consists of 885 genes, 870 metabolites, and 1240
reactions. During the reconstruction process, 36 putative sugar
transporters were reannotated and the metabolisms of 7 sugars
were illuminated. Essentiality study was conducted to predict
essential genes on different growth media. Key factors
affecting cell growth and ethanol formation were investigated
by the use of constraint-based analysis. Furthermore, the
uptake systems and metabolic routes of xylose were elucidated,
and the optimization strategies for the overproduction of
ethanol were proposed from both genetic and environmental
perspectives. CONCLUSIONS: Systems biology modelling has proven
to be a powerful tool for targeting metabolic changes. Thus,
this systematic investigation of the metabolism of S. stipitis
could be used as a starting point for future experiment designs
aimed at identifying the metabolic bottlenecks of this
important yeast.

This model is hosted on
BioModels Database
and identified by:
MODEL1507180026.
To cite BioModels Database, please use:
BioModels Database:
An enhanced, curated and annotated resource for published
quantitative kinetic models.

To the extent possible under law, all copyright and related or
neighbouring rights to this encoded model have been dedicated to
the public domain worldwide. Please refer to
CC0
Public Domain Dedication for more information.