Associations with sufficient power for detection (> = 80%) that failed to replicate.

Pub OR = published odds ratio. Rep OR = 23andMe attempted replication odds ratio. Power = estimated power to detect association. aCOPD = Chronic Obstructive Pulmonary Disease. This analysis included smokers only. bIBD = Inflammatory Bowel Disease. cThis SNP was initially associated with IBD, but replicated only for Crohn's disease [39], which is a subtype of IBD. Latiano et al. also replicates rs7517847 with Crohn's disease, but not with ulcerative colitis, which is the other major subtype of IBD [14]. dThis association was curated into the GWAS catalog as significantly associated with Parkinson's disease but was not identified by the authors as significant.