Structural Insights into the Design of Nonpeptidic Isothiazolidinone- Containing Inhibitors of Protein Tyrosine Phosphatase 1B

Structural Insights into the Design of Nonpeptidic Isothiazolidinone- Containing Inhibitors of Protein Tyrosine Phosphatase 1B Descriptor: GLYCEROL, MAGNESIUM ION, N-{(1S)-2-{4-[(5R)-1,1-DIOXIDO-3-OXOISOTHIAZOLIDIN-5-YL]PHENYL}-1-[5-(TRIFLUOROMETHYL)-1H-BENZIMIDAZOL-2-YL]ETHYL}-2,2,2-TRIFLUOROACETAMIDE, ... Authors: Ala, P.J, Gonneville, L, Hillman, M, Becker-Pasha, M, Yue, E.W, Douty, B, Wayland, B, Polam, P, Crawley, M.L, McLaughlin, E, Sparks, R.B, Glass, B, Takvorian, A, Combs, A.P, Burn, T.C, Hollis, G.F, Wynn, R. Deposit date: 2006-05-21 Release date: 2006-09-27 Last modified: 2023-12-13 Method: X-RAY DIFFRACTION (1.9 Å) Cite: Structural Insights Into the Design of Nonpeptidic Isothiazolidinone-Containing Inhibitors of Protein- Tyrosine Phosphatase 1B. J.Biol.Chem., 281, 2006

蛋白质酪氨酸磷酸酶1B（Protein Tyrosine Phosphatase 1B）的非肽类含异噻唑啉酮（Isothiazolidinone）抑制剂设计的结构解析；描述符：甘油（Glycerol）、镁离子（Magnesium Ion）、N-{(1S)-2-{4-[(5R)-1,1-二氧代-3-氧代异噻唑烷-5-基]苯基}-1-[5-(三氟甲基)-1H-苯并咪唑-2-基]乙基}-2,2,2-三氟乙酰胺，……；作者：Ala, P.J.、Gonneville, L.、Hillman, M.、Becker-Pasha, M.、Yue, E.W.、Douty, B.、Wayland, B.、Polam, P.、Crawley, M.L.、McLaughlin, E.、Sparks, R.B.、Glass, B.、Takvorian, A.、Combs, A.P.、Burn, T.C.、Hollis, G.F.、Wynn, R.；存入日期：2006-05-21；发布日期：2006-09-27；最后修改日期：2023-12-13；实验方法：X射线衍射（X-RAY DIFFRACTION），分辨率1.9埃（Å）；引用文献：《Structural Insights Into the Design of Nonpeptidic Isothiazolidinone-Containing Inhibitors of Protein Tyrosine Phosphatase 1B》，《J.Biol.Chem.》，第281卷，2006年