Regulation of gene expression in INS-1E cells after cyclosporine treatment.

Gene expression was measured by real-time qRT-PCR in INS-1E cells 72 h after treatment with 8.3 µM (10 µg/ml) cyclosporine (n = 3, respectively) and was determined relative to expression of mitATPase6, which served as a housekeeping gene. Gene expression in untreated INS-1E cells was set to 100 and values for cyclosporine treatment represent transcript abundance relative to control. Non-parametric Mann-Whitney-U-Test was used to compare cyclosporine treated and control groups. Results are considered significant at p