An intersegmental single-cell profile reveals aortic heterogeneity [aorta]

The continuous inter-segmental aortic profile has been rarely reported at the single-cell level. To reveal aortic heterogeneity, we identified 15 cell subtypes from five continuous aortic segments by marker genes and functional definitions. In conclusion, our study provides a more comprehensive segmental single-cell transcriptome of the aorta at the physiological level, inspiring new ideas for diagnosis and intervention targets in the pathogenesis of aortic diseases. Furthermore, a novel construction system of VSMCs was proposed to replace the traditional classification. a segmental transcriptome of aortic cells from five male wild-type C57BL/6 mice