X-ray structure of the p53-MDM2 inhibitor NMI801 bound to HDM2 at 2.1A resolution

X-ray structure of the p53-MDM2 inhibitor NMI801 bound to HDM2 at 2.1A resolution Descriptor: 6-chloranyl-3-[3-[(1~{S})-1-(4-chlorophenyl)ethyl]-5-phenyl-imidazol-4-yl]-~{N}-[2-[4-(2-oxidanylidene-1,3-oxazinan-3-yl)piperidin-1-yl]pyridin-3-yl]-1~{H}-indole-2-carboxamide, Human E3 Ubiquitin-Protein Ligase MDM2 Authors: Kallen, J. Deposit date: 2018-11-01 Release date: 2019-11-20 Last modified: 2024-01-24 Method: X-RAY DIFFRACTION (2.1 Å) Cite: p53 dynamics vary between tissues and are linked with radiation sensitivity To be published

分辨率为2.1埃的、与人类双微体2（HDM2）结合的p53-MDM2抑制剂NMI801的X射线晶体结构。结构描述物：6-氯-3-[3-[(1S)-1-(4-氯苯基)乙基]-5-苯基-咪唑-4-基]-N-[2-[4-(2-氧代-1,3-恶嗪烷-3-基)哌啶-1-基]吡啶-3-基]-1H-吲哚-2-甲酰胺；HDM2即人类E3泛素蛋白连接酶MDM2。作者：Kallen, J. 存入日期：2018-11-01；发布日期：2019-11-20；最后修改日期：2024-01-24。实验方法：X射线衍射（2.1 Å）。引用文献：《p53动力学存在组织特异性差异，并与辐射敏感性相关》，待发表。