FineMAV: Simulations

Simulated data describing allele frequency and CADD scores of genomic windows spanning 1000 SNPs under different selection scenarios (s=0; s=0.001; s=0.007; s=0.01; each 100 replicates). Selected variant is always in the middle of a window (rs500). Parameters for migration rate were taken from Ryan N.Gutenkunst, 2009, dx.doi.org/10.1371/journal.pgen.1000695:Migration rate between Africa-Europe: 3*10-5Migration rate between Asia-Africa: 1.9*10-5Migration rate between Asia-Europe: 9.6*10-5 The selection started after populations split and lasted for 900 generations.Initial Ne for Africans, Europeans, East Asians: 10000, 5000, 4000Final Ne for Africans, Europeans, East Asians: 20000, 40000, 70000Sex ratio: 1:1 Mating model: random mating. Mutation rate per marker: 1*10-8 per generation Selection model: additive本数据集为模拟数据，描述了不同选择场景（s=0；s=0.001；s=0.007；s=0.01，各设置100次重复）下，覆盖1000个单核苷酸多态性（Single Nucleotide Polymorphism, SNP）的基因组窗口的等位基因频率与综合注释依赖损耗（CADD, Combined Annotation Dependent Depletion）评分。所选定的变异位点始终位于基因组窗口的中央，位点编号为rs500。迁移率参数取自Ryan N. Gutenkunst等人2009年的研究（doi:10.1371/journal.pgen.1000695），具体参数如下：非洲与欧洲群体间的迁移率为3×10^-5，亚洲与非洲群体间的迁移率为1.9×10^-5，亚洲与欧洲群体间的迁移率为9.6×10^-5。选择压力在群体分化后开始施加，持续时长为900代。非洲、欧洲、东亚人群的初始有效种群大小（Ne, effective population size）分别为10000、5000、4000，最终有效种群大小分别为20000、40000、70000。群体性别比例为1:1，交配模式为随机交配。每个标记的突变率为每代1×10^-8，选择模型为加性选择模型。