The Clinical Efficacy of Chemotherapy Determined by Histoculture Drug Response Assays in Patients with Colorectal Cancer

Interventions: The Drug-sensitive group:Patients were regarded as sensitive to at least one kind of the drug in vitro HDRA assay;The Drug-resistant group:Patients who were diagnosed as resistant to all agents of their chemotherapy regiments in vitro HDRA assay;The Drug-empirical group:Patients who just underwent chemotherapy empirically without the direction of HDRA Primary outcome(s): in vitro-in vivo correlations Study Design: Factorial