Crystal structure of Trypanosoma cruzi histone deacetylase DAC2 complexed with a hydroxamate inhibitor

Crystal structure of Trypanosoma cruzi histone deacetylase DAC2 complexed with a hydroxamate inhibitor Descriptor: (E)-3-dibenzofuran-4-yl-N-oxidanyl-prop-2-enamide, Histone deacetylase DAC2, POTASSIUM ION, ... Authors: Ramos-Morales, E, Marek, M, Romier, C. Deposit date: 2021-10-18 Release date: 2021-12-15 Last modified: 2024-01-31 Method: X-RAY DIFFRACTION (2.3 Å) Cite: Species-selective targeting of pathogens revealed by the atypical structure and active site of Trypanosoma cruzi histone deacetylase DAC2. Cell Rep, 37, 2021克氏锥虫（Trypanosoma cruzi）组蛋白去乙酰化酶DAC2与异羟肟酸类抑制剂(E)-3-二苯并呋喃-4-基-N-羟基丙-2-烯酰胺结合的晶体结构。描述项：(E)-3-二苯并呋喃-4-基-N-羟基丙-2-烯酰胺、组蛋白去乙酰化酶DAC2、钾离子（POTASSIUM ION）等。作者：Ramos-Morales, E、Marek, M、Romier, C。提交日期：2021-10-18，发布日期：2021-12-15，最后修改日期：2024-01-31。实验方法：X射线衍射（2.3埃（Å））。引用文献：《通过克氏锥虫组蛋白去乙酰化酶DAC2的非典型结构与活性位点实现病原体的物种选择性靶向》，《Cell Reports》（Cell Rep），第37卷，2021年