Changes in circulating miRNA expression in right heart remodeling due to pulmonary hypertension

Clinical practice currently faces a significant shortfall in specific biomarkers needed for diagnosing right ventricular (RV) remodeling in patients with pulmonary hypertension (PH). MiRNAs are crucial regulators of cardiovascular development, influencing processes like angiogenesis, cardiomyocyte differentiation, cell cycle, cardiac electrical activity, and cardiomyocyte growth. Furthermore, circulating miRNAs are cell-or tissue-specific, relatively stable in serum, and resistant to degradation factors. These properties make serum miRNAs possible promising biomarkers for predictive diagnosis of cardiovascular disease (CVD). This study systematically screened and identified candidate serum miRNAs as potential diagnostic biomarkers for RV remodeling in PH patients. Overall design: Serum samples from Sprague - Dawley rats surviving 4 weeks after Pulmonary artery banding (PAB) and sham surgery were subjected to miRNA high-throughput sequencing and analyzed for differences.