TCR-repertoire analysis Reference Datasets from huARdb

This dataset contains two processed metadata files supporting the T cell receptor (TCR) repertoire analysis described in "MHC restriction is structurally encoded by the T cell receptor germline" online in biorxiv. doi: https://doi.org/10.64898/2026.09.24.754241 Files included: huARdb_v2_5_cell_discovery_dataset.TCR.checked.csv — TCR sequence dataset derived from the huARdb v2 TCRαβ repertoire atlas. 2025_huARdb_sample_information_v2_7.csv — Corresponding donor/sample metadata, including HLA typing information. These files originate from previously published, publicly available data generated by the Liu Lab (Zhejiang University–University of Edinburgh Institute) as part of the huARdb v2 database (Xue et al., Cell Discovery, 2025). They have been prepared and formatted to serve as direct inputs to the analysis code accompanying the manuscript, available at: https://github.com/Nan-Wang-2025/TCR-germline-repertoire-analysis. Users wishing to reproduce the TCR repertoire analyses (HLA-A*02 cohort stratification, TRAV/TRBV gene enrichment, and Vα-Vβ pairing enrichment) described in the manuscript should download both files and place them in the working directory of the huardb_TCR_germline_analysis.ipynb notebook. Citation: If you use these files, please cite both this dataset and the original huARdb v2 publication (Xue et al., Cell Discovery, 2025).