De-identified patient-level data for a single-centre cohort study of intraoperative ultrasound-guided excision in myxofibrosarcoma (2008-2024)

This dataset contains the de-identified individual patient data underlying a single-centre retrospective cohort study of intraoperative ultrasound-guided excision for myxofibrosarcoma of the extremities and trunk. Sixty-five patients treated at one tertiary referral centre between January 2008 and December 2024 are included, with follow-up updated through June 2025. Patients are divided by treatment era into a conventional excision cohort (2008-2013, n = 15) and an ultrasound-guided excision cohort (2014-2024, n = 50). Three patients in the ultrasound-guided cohort are flagged as excluded from the primary comparative analysis (one with distant metastasis at presentation, two who underwent marginal rather than wide excision), giving a primary analysis cohort of 62 patients. The file provides 27 variables per patient: demographic and tumour characteristics (sex, age, anatomical site group, maximum diameter, depth relative to fascia, FNCLCC grade, presence of an MRI tail sign, clinical presentation at referral), treatment variables (intended extent of resection, perioperative radiotherapy and chemotherapy), the primary margin endpoint (R0 versus R1, and among R0 margins a clearance of at least 1 mm versus less than 1 mm), and time-to-event data for overall survival, local recurrence-free survival, and distant metastasis-free survival. The dataset is analysis-ready and reproduces every patient-level result reported in the associated article, including the margin comparison, the Kaplan-Meier survival estimates, and the internal comparison between treatment eras. A codebook defining every variable is included. The matching-adjusted indirect comparisons reported in the article used aggregate data reconstructed from Kaplan-Meier curves published by seven external cohorts. Those reconstructed data are not included here; the individual patient data in this file are the index-cohort input to those comparisons. All direct identifiers, the date of birth, and all calendar event dates have been removed. Only the calendar year of surgery is retained, because it defines the treatment-era cohort. Time to event is provided as an interval in months from the date of surgery. Age is rounded to one decimal place and top-coded at 90 years.本数据集包含一项单中心回顾性队列研究（retrospective cohort study）的去标识化个体患者数据（individual patient data），该研究针对四肢与躯干黏液纤维肉瘤（myxofibrosarcoma）的术中超声引导切除术（intraoperative ultrasound-guided excision）展开。 本研究纳入2008年1月至2024年12月间于某三级转诊中心（tertiary referral centre）接受治疗的65例患者，随访数据更新至2025年6月。按照治疗时代将患者分为常规切除术队列（cohort）（2008-2013年，n = 15）与超声引导切除术队列（2014-2024年，n = 50）。超声引导切除术队列中有3例患者被标记为排除于主要比较分析之外（1例就诊时已存在远处转移，2例接受的是边缘性切除而非广泛性切除），因此主要分析队列共包含62例患者。 每份患者记录包含27个变量，涵盖人口统计学与肿瘤特征（性别、年龄、解剖部位分组、最大直径、筋膜相对深度、FNCLCC分级（FNCLCC grade）、MRI尾征（MRI tail sign）、转诊时的临床表现）、治疗相关变量（预期切除范围、围手术期放疗与化疗）、主要切缘（margin）结局指标（R0切缘（R0 margin）与R1切缘（R1 margin），其中R0切缘还细分为切缘≥1mm与<1mm），以及总生存期（overall survival）、局部无复发生存期（local recurrence-free survival）与远处无转移生存期（distant metastasis-free survival）的时间事件数据。 本数据集已完成分析就绪，可复现关联论文中报告的所有患者水平结果，包括切缘比较、Kaplan-Meier生存估计（Kaplan-Meier survival estimates）以及治疗时代间的内部比较。文件中附带了定义所有变量的编码手册（codebook）。 论文中报告的匹配校正间接比较（matching-adjusted indirect comparisons）使用了从7个外部队列发表的Kaplan-Meier曲线（Kaplan-Meier curves）重构的汇总数据（aggregate data），此类重构数据未包含在本数据集中；本文件中的个体患者数据为上述比较的索引队列（index-cohort）输入数据。 所有直接标识符、出生日期以及所有日历事件日期均已移除，仅保留手术年份以用于划分治疗时代队列。时间事件数据以手术日期起算的月数区间形式提供。年龄已四舍五入至小数点后一位，并以90岁为上限进行截尾处理（top-coded）。